Muscadine Grape Extract

The muscadine grape (Vitisrotundifolia) is native to North Carolina and other parts of the southeastern region of the United States. These large, thick-skinned and seeded grapes grow in small, loose clusters and are often harvested as individual berries. A mixture of both purple and bronze grapes is carefully crushed to remove the juice and the remaining pomace (skin, seeds and pulp) is extracted with heated water. The water extract is then fermented to remove the natural occurring sugars and concentrated for superior potency. Muscadine grape extract is a rich source of polyphenols and other nutrients, offering health benefits.

Health Benefits

Muscadine grapes have been found to contain antioxidant, antibacterial, anticancer and antinflammatory properties.1-8 It has been suggested in a preclincal study that muscadine grapes may reduce inflammation and blood lipid levels (e.g., cholesterol and triglycerides) but improve blood glucose control and insulin sensitivity, indicating that Muscadine grapes may reduce the risk of obesity-related metabolic disorders.9


  1. Xu C, Yagiz Y, Marshall S, Li Z, Simonne A, Lu J, Marshall MR. Application of muscadine grape (Vitis rotundifolia Michx.) pomace extract to reduce carcinogenic acrylamide. Food Chem. 2015 Sep 1;182:200-8. doi: 10.1016/j.foodchem.2015.02.133. Epub 2015 Mar 5. PubMed PMID: 25842328.
  2. Xu C, Yagiz Y, Hsu WY, Simonne A, Lu J, Marshall MR. Antioxidant, antibacterial, and antibiofilm properties of polyphenols from muscadine grape (Vitis rotundifolia Michx.) pomace against selected foodborne pathogens. J Agric Food Chem. 2014 Jul 16;62(28):6640-9. doi: 10.1021/jf501073q. Epub 2014 Jul 3. PubMed PMID: 24865879.
  3. Xu C, Yagiz Y, Borejsza-Wysocki W, Lu J, Gu L, Ramírez-Rodrigues MM, Marshall MR. Enzyme release of phenolics from muscadine grape (Vitis rotundifolia Michx.) skins and seeds. Food Chem. 2014 Aug 15;157:20-9. doi: 10.1016/j.foodchem.2014.01.128. Epub 2014 Feb 13. PubMed PMID: 24679747.
  4. You Q, Chen F, Wang X, Sharp JL, You Y. Analysis of phenolic composition of Noble muscadine (Vitis rotundifolia) by HPLC-MS and the relationship to its antioxidant capacity. J Food Sci. 2012 Oct;77(10):C1115-23. doi: 10.1111/j.1750-3841.2012.02888.x. Epub 2012 Aug 27. PubMed PMID: 22924759.
  5. Sandhu AK, Gu L. Antioxidant capacity, phenolic content, and profiling of phenolic compounds in the seeds, skin, and pulp of Vitis rotundifolia (Muscadine Grapes) As determined by HPLC-DAD-ESI-MS(n). J Agric Food Chem. 2010 Apr 28;58(8):4681-92. doi: 10.1021/jf904211q. PubMed PMID: 20334341.
  6. Mertens-Talcott SU, Lee JH, Percival SS, Talcott ST. Induction of cell death in Caco-2 human colon carcinoma cells by ellagic acid rich fractions from muscadine grapes (Vitis rotundifolia). J Agric Food Chem. 2006 Jul 26;54(15):5336-43. PubMed PMID: 16848514.
  7. Greenspan P, Bauer JD, Pollock SH, Gangemi JD, Mayer EP, Ghaffar A, Hargrove JL, Hartle DK. Antiinflammatory properties of the muscadine grape (Vitis rotundifolia). J Agric Food Chem. 2005 Nov 2;53(22):8481-4. PubMed PMID: 16248541.
  8. Bralley EE, Hargrove JL, Greenspan P, Hartle DK. Topical anti-inflammatory activities of Vitis rotundifolia (muscadine grape) extracts in the tetradecanoylphorbol acetate model of ear inflammation. J Med Food. 2007 Dec;10(4):636-42. PubMed PMID: 18158834.
  9. Gourineni V, Shay NF, Chung S, Sandhu AK, Gu L. Muscadine grape (Vitis rotundifolia) and wine phytochemicals prevented obesity-associated metabolic complications in C57BL/6J mice. J Agric Food Chem. 2012 Aug 8;60(31):7674-81. doi: 10.1021/jf3013663. Epub 2012 Jul 27. Erratum in: J Agric Food Chem. 2014 Oct 29;62(43):10621. PubMed PMID: 22788667.