Citrus bioflavonoids

Citrus bioflavonoids include lemon bioflavonoids, orange bioflavonoids, grapefruit bioflavonoids, and hesperidin complex. They are obtained from the inner peels of lemon, orange, and grapefruits. The citrus peels are crushed and then undergo a series of extractions. The resulting mixture is dried into a powder form.

Major Health Benefits

Bioflavonoids are a family of compounds found naturally in plants and act as antioxidants and anti-inflammatory agents.1,2 Adequate consumption of dietary bioflavonoids has been associated with decreased risk for cancer, cardiovascular disease, and other chronic diseases. Bioflavonoids play important roles in cell signaling pathways that regulate cell growth and death (apoptosis) and in influencing pathways that may decrease inflammation, inhibit tumor growth, excrete toxic chemicals from the body, and prevent excessive blood clotting.3-5


  1. Parhiz H, Roohbakhsh A, Soltani F, Rezaee R, Iranshahi M. Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models. Phytother Res. 2015 Mar;29(3):323-31. PMID: 25394264.
  2. Mohanty S, Maurya AK, Jyotshna, Saxena A, Shanker K, Pal A, Bawankule DU. Flavonoids rich fraction of Citrus limetta fruit peels reduces proinflammatory cytokine production and attenuates malaria pathogenesis. Curr Pharm Biotechnol. 2015;16(6):544-52. PMID: 25860065.
  3. Williams RJ, Spencer JP, Rice-Evans C. Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med. 2004 Apr 1;36(7):838-49. PMID: 15019969.
  4. Higdon, J. Flavonoids. Linus Pauling Institute, Oregon State University. 2005. (Reviewed by Dashwood, RH in 2008). (Effects on Cell-Signaling Pathways) Accessed in July 2015.
  5. Bagli E, Stefaniotou M, Morbidelli L, Ziche M, Psillas K, Murphy C, Fotsis T. Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3′-kinase activity. Cancer Res. 2004 Nov 1;64(21):7936-46. PubMed PMID: 15520200.