Alpha Lipoic Acid

Alpha lipoic acid is a sulfur-containing compound produced within the body. Alpha lipoic acid can be found in foods such as: liver, spinach and broccoli.1

Major Health Benefits

Alpha lipoic acid plays a role as a cofactor in carbohydrate metabolism and the production of energy (ATP, the energy currency in the body). Both water and fat-soluble, alpha lipoic acid are recognized for their antioxidant properties and are involved in the recycling of other antioxidants such as vitamins C and E, and glutathione.2,3 Alpha lipoic acid may also play a role in lowering blood glucose level by improving insulin sensitivity and glucose utilization in the cell as well as reducing peripheral nerve damage in individuals with type 2 diabetes.4,5

Cautions

Although there are few adverse effects from the consumption of Alpha Lipoic Acid, the most common side effect is an allergic reaction that may create hives, rashes, and itchiness on the skin.4 Other symptoms may include: diarrhea, vomiting, and nausea.6 Individuals currently taking medication that lowers blood glucose should consult a physician before taking alpha lipoic acid supplements.

References

  1. Higdon, J. Lipoic Acid. Linus Pauling Institute, Oregon State University. 2002. (Reviewed by Hagen, TM in 2012). (Food Sources) http://lpi.oregonstate.edu/mic/dietary-factors/lipoic-acid Accessed in July 2015
  2. Ghibu S, Richard C, Delemasure S, Vergely C, Mogosan C, Muresan A. [An endogenous dithiol with antioxidant properties: alpha-lipoic acid, potential uses in cardiovascular diseases]. Ann Cardiol Angeiol (Paris). 2008 Jun;57(3):161-5.PMID: 18571145.
  3. Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic Biol Med. 1997;22(1-2):359-78.PMID: 8958163.
  4. Kamenova P. Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid. Hormones (Athens). 2006 Oct-Dec;5(4):251-8.PMID: 17178700.
  5. Higdon, J. Lipoic Acid. Linus Pauling Institute, Oregon State University. 2002. (Reviewed by Hagen, TM in 2012). (Diabetic Neuropathy) http://lpi.oregonstate.edu/mic/dietary-factors/lipoic-acid Accessed in July 2015
  6. Higdon, J. Lipoic Acid. Linus Pauling Institute, Oregon State University. 2002. (Reviewed by Hagen, TM in 2012). (Safety) http://lpi.oregonstate.edu/mic/dietary-factors/lipoic-acid Assessed in July 2015