Why was this study done?

Population studies have long shown a lower incidence of heart disease in cultures who consume a large portion of their diet as cold-water fish. These observations have led to the hypothesis that omega-3 fatty acids (EPA, DHA) might be responsible for the cardiovascular effects of these diets. This study was designed to investigate the relationship of differing doses of omega-3 fish oil (1, 3, 6 grams a day) on cardiovascular risk factors.

What did the study find?

The 1-gram/day dose did not alter EPA status significantly following 4 weeks of supplementation. The 3-gram/day dose was sufficient to alter EPA status, but only the 6-gram/day dose was able to significantly alter very low-density lipoproteins (VLDL) and triglycerides.

Plasma Lipids on Three Levels of Fish Oil Intake in Healthy Human Subjects
Authors: Jensen CD, et al. Nutr Rep Int, 1988. 38(1): p. 165-172.
PDF Manuscript: Nutr Rep Int, 1988.