Why was this study done? This study was designed to help understand the progression of parainfluenza infection for the development of potential anti-viral strategies.
What did the study find?
The study suggested that the most direct strategy for preventing infection may be by interfering with the initial receptor binding of the virus to the host cell.
Human parainfluenza virus infection of the airway epithelium: viral hemagglutinin-neuraminidase regulates fusion protein activation and modulates infectivity.
Authors: Palermo LM, Porotto M, Yokoyama CC, Palmer SG, Mungall BA, Greengard O, Niewiesk S, Moscona A. J Virol. 2009 Jul;83(13):6900-8.
PubMed Citation, PMID: 19386708.
PDF Manuscript: J Virol 2009.