Why was this study done?

Homocysteine is an amino acid found in the blood that is produced in the body during normal protein metabolism. High homocysteine levels are considered a risk factor for cardiovascular disease. This study was designed to understand the relationship between B vitamin status and homocysteine levels.

What did the study find?

There was a significant lowering of homocysteine (by 12 %) in participants who were supplemented with 400 mcg folic acid, 300 mcg B12, and 4 mg B6 for eight weeks.

Homocysteine Lowering in Men and Women with Normal Plasma Homocysteine Levels.

Authors: Spiller G, Bruce B, Jensen C. J Am Coll Nutr, 1998. 17: 530.
PDF Abstract: J Am Coll Nutr, 1998.