Vitamin K1 vs. K2
Three misleading information to be clarified on cyanocobalamin and methylcobalamin:
- Question 1) Is Cyanocobalamin toxic? – Answer 1) No. Cyanocobalamin is very safe! Since cyanocobalamin is very safe, cyanide toxicity is treated by injecting hydroxocobalamin, so that body can turn cyanide into cyanocobalamin by making cyanide bind with cobalamin in the cell and then the cyanocobalamin to be excreted via urine safely. There are higher amount of cyanide in the food than the cyanide in the cyanocobalamin from the dietary supplement. For example, if you eat ONLY 1 g of almond (1 whole piece), you can ingest 15.6 times more cyanide than taking 1 serving of cyanocobalamin from Shaklee B complex.
- Question 2) Methylcobalamin is natural? – Answer 2) No. Methylcobalamin is synthesized, and the starting material for its synthesis can be cyanocobalamin or hydroxocobalamin.
- Question 3) People with methylation problem should take methylcobalamin since supplemental methylcobalamin is the ready-to-work coenzyme (cofactor) form. – Answer 3) No. Both the methyl-group from orally ingested methylcobalamin and the cyanide-group from cyanocobalamin have to be removed in the cell to become a free form of cobalamin without the methyl-group or cyanide-group. Then, the free cobalamin will be incorporated into the process to resynthesize the cofactor form of methylcobalamin by receiving the methyl-group in the cell or the cofactor form of adenosylcobalamin by receiving adenosyl-group in the cell. Therefore, (1) methylcobalamin follows the same route of intracellular processing as cyanocobalamin, (2) People with methylation defect can utilize cyanocobalamin, (3) Supplementing methylcobalamin is unlikely to be more advantageous than supplementing cyanocobalamin for People with methylation defect as well as general population.
- Please find detailed explanations / answers in the pdf.