Why was this study done?
Meals that are high in fat and carbohydrates are well-known to increase oxidative stress and inflammation. This study was designed to explore the notion that an antioxidant supplement high in polyphenols and resveratrol principally from muscadine grapes could blunt the oxidative effects of a high fat/carbohydrate meal.
What did the study find?
The participants who were supplemented with the antioxidant supplement had dramatically lower levels of reactive oxygen species (pro-oxidants) and inflammation when compared to a placebo group.
A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal.
Authors: Ghanim H, Sia CL, Korzeniewski K, Lohano T, Abuaysheh S, Marumganti A, Chaudhuri A, Dandona P. J Clin Endocrinol Metab. 2011 May;96(5):1409-14.
PubMed Citation, PMID: 21289251.
HTML Manuscript, PMCID: PMC3085195.