Chardonnay Grape Seed Extract

Chardonnay Grape Seed Extract (Vitis vinifera) comes from the Chardonnay grapes originated in Eastern France. The most abundant active compounds in chardonnay grape seed extracts are polyphenols.

Health Benefits

Chardonnay grape seeds and polyphenols in chardonnay grape seeds may have antioxidant, anti-inflammatory, anti-obesity and anti-stress effects as well as cholesterol lowering and nootropic (enhancing cognition) effects as observed in preclinical studies.1-5 Among grape seeds, chardonnay seeds contain the highest levels of the polyphenol epicatechin.6 Epicatechin has been shown to be important for vascular health and maintaining healthy blood pressure.7,8 Several studies emphasized that vascular health is positively associated with cognitive health.9-11


  1. Kim H, Bartley GE, Arvik T, Lipson R, Nah SY, Seo K, Yokoyama W. Dietary supplementation of chardonnay grape seed flour reduces plasma cholesterol concentration, hepatic steatosis, and abdominal fat content in high-fat diet-induced obese hamsters. J Agric Food Chem. 2014 Feb 26;62(8):1919-25. doi: 10.1021/jf404832s. Epub 2014 Feb 18. PubMed PMID: 24517872.
  2. Décordé K, Teissèdre PL, Sutra T, Ventura E, Cristol JP, Rouanet JM. Chardonnay grape seed procyanidin extract supplementation prevents high-fat diet-induced obesity in hamsters by improving adipokine imbalance and oxidative stress markers. Mol Nutr Food Res. 2009 May;53(5):659-66. PubMed PMID: 19035554.
  3. Kim H, Kim DH, Seo KH, Chon JW, Nah SY, Bartley GE, Arvik T, Lipson R, Yokoyama W. Modulation of the intestinal microbiota is associated with lower plasma cholesterol and weight gain in hamsters fed chardonnay grape seed flour. J Agric Food Chem. 2015 Feb 11;63(5):1460-7. PubMed PMID: 25598538.
  4. Sreemantula S, Nammi S, Kolanukonda R, Koppula S, Boini KM. Adaptogenic and nootropic activities of aqueous extract of Vitis vinifera (grape seed): an experimental study in rat model. BMC Complement Altern Med. 2005 Jan 19;5:1. PubMed PMID: 15656916; PubMed Central PMCID: PMC547917.
  5. Wang J, Ferruzzi MG, Ho L, Blount J, Janle EM, Gong B, Pan Y, Gowda GA, Raftery D, Arrieta-Cruz I, Sharma V, Cooper B, Lobo J, Simon JE, Zhang C, Cheng A, Qian X, Ono K, Teplow DB, Pavlides C, Dixon RA, Pasinetti GM. Brain-targeted proanthocyanidin metabolites for Alzheimer’s disease treatment. J Neurosci. 2012 Apr 11;32(15): 5144-50. doi: 10.1523/JNEUROSCI.6437-11.2012. PubMed PMID:22496560; PubMed Central PMCID: PMC3348654.
  6. Yilmaz Y, Toledo RT. Major flavonoids in grape seeds and skins: antioxidant capacity of catechin, epicatechin, and gallic acid. J Agric Food Chem. 2004 Jan 28;52(2):255-60. PubMed PMID: 14733505.
  7. Schroeter H, Heiss C, Balzer J, Kleinbongard P, Keen CL, Hollenberg NK, Sies H, Kwik-Uribe C, Schmitz HH, Kelm M. (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1024-9. Epub 2006 Jan 17. PubMed PMID: 16418281; PubMed Central PMCID: PMC1327732.
  8. Taubert, D., Roesen, R., Lehmann, C., Jung, N., Schomig, E. Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial. JAMA 298:49-60, 2007.
  9. Bolduc V, Thorin-Trescases N, Thorin E. Endothelium-dependent control of cerebrovascular functions through age: exercise for healthy cerebrovascular aging. Am J Physiol Heart Circ Physiol. 2013 Sep 1;305(5):H620-33. doi: 10.1152/ajpheart.00624.2012. Epub 2013 Jun 21. Review. PubMed PMID: 23792680.
  10. Katusic ZS, Austin SA. Endothelial nitric oxide: protector of a healthy mind. Eur Heart J. 2014 Apr;35(14):888-94. doi: 10.1093/eurheartj/eht544. Epub 2013 Dec 18. Review. PubMed PMID: 24357508; PubMed Central PMCID: PMC3977136.
  11. Barbour JA, Howe PR, Buckley JD, Bryan J, Coates AM. Nut consumption for vascular health and cognitive function. Nutr Res Rev. 2014 Jun;27(1):131-58. doi: 10.1017/S0954422414000079. Epub 2014 May 27. Review. PubMed PMID: 24866624.